A hiponatremia como fator preditivo da perda precoce do transplante hepático na modalidade intervivos

Conteúdo do artigo principal

Sofia Abdalla
Rogério Camargo Pinheiro Alves
Eduardo Antunes da Fonseca
Rodrigo Vicenzi
José Eduardo Gonçalves
Jaques Waisberg

Resumo

Introdução: O transplante hepático intervivos representa alternativa para reduzir a falta de doação de órgãos. Objetivo: Analisar a influência da natremia como fator preditivo da perda precoce do transplante hepático nos três primeiros meses na modalidade intervivos. Método: Estudo retrospectivo, observacional e analítico de 78 doentes adultos submetidos ao transplante de fígado com doador vivo. A média etária foi 50,7±6,8 anos (18 a 65 anos) e dividiu-se os doentes transplantados em grupo I, com 62 (79,5%) pacientes com sobrevivência do enxerto superior a três meses, e grupo II com 16 (20,5%), que faleceram e/ou apresentaram falha do enxerto no prazo de até três meses após a realização do transplante hepático. Foram analisadas as seguintes variáveis: sexo, idade, etiologia da doença hepática e o nível sérico de sódio no momento do transplante. Foi considerada “perda precoce” a sobrevivência do enxerto hepático menor que três meses após a realização do transplante. Na avaliação dos fatores de risco para perda precoce do enxerto hepático foram utilizados o teste do χ2, o teste t de Student e a análise uni e multivariada. A análise de sobrevivência do enxerto foi realizada pelo modelo de Kaplan-Meier. Resultados: Sexo (p=0,4) e idade (p=0,67) não apresentaram diferença significante. O nível sérico de sódio foi significantemente (p=0,01) maior no grupo I do que no grupo II. Conclusão: Os valores da natremia estão associados à maior probabilidade de sucesso no transplante hepático na modalidade intervivos.

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Referências

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