Interações em processos fisiológicos: a importância da dinâmica entre matriz extracelular e proteoglicanos
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Resumo
A matriz extracelular foi considerada por muito tempo uma estrutura inerte constituída por várias proteínas e polissacarídeos sintetizados e secretados pelas células para o preenchimento do espaço extracelular. Atualmente sabe-se que, além de auxiliar na ligação das células para a formação dos tecidos, a matriz extracelular tem papel importante no controle do crescimento e na diferenciação celular e, nessa interação, moléculas como proteoglicanos, glicosaminoglicanos, proteases e glicosidases desencadeam eventos de sinalização celular. Os proteoglicanos presentes na matriz extracelular realizam importantes funções, dentre elas, regulação da atividade de moléculas sinalizadoras, controle do tráfego de células e moléculas, atuação como coreceptores e interação com proteínas fibrosas da matriz. Esta revisão tem enfoque nas características estruturais da matriz extracelular, de proteoglicanos e do papel fundamental das interações celulares.
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Referências
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