O papel dos desreguladores endócrinos na fisiopatologia da endometriose: revisão da literatura

Conteúdo do artigo principal

Bianca Bianco
Denise Maria Christofolini
Ângela Mara Bentes de Souza
Caio Parente Barbosa

Resumo

O efeito prejudicial que os desreguladores endócrinos podem ter na saúde humana está chamando a atenção da comunidade científica. Essas substâncias são capazes de mimetizar, bloquear ou modular a resposta endócrina por meio da interação com os receptores dos hormônios esteroides e incluem substâncias como pesticidas, fungicidas, dioxinas, ftalatos, bisfenol A, fitoestrogênios, entre outros. A endometriose é uma doença ginecológica comum, que acomete cerca de 15% das mulheres em período reprodutivo e 50% das mulheres com problemas de fertilidade. Muitas teorias foram propostas para tentar explicar o desenvolvimento das lesões. Todavia, não existe, até o momento, uma teoria única que identifique e explique todos os aspectos clínicos dessa doença considerada multifatorial. Recentemente, contaminantes ambientais têm sido implicados na fisiopatologia da endometriose. Este trabalho teve por objetivo realizar uma revisão crítica da literatura médica sobre a influência de compostos ambientais no desenvolvimento da endometriose.

Detalhes do artigo

Seção
Artigos de Revisão

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