The diosmin antioxidant effect: an integrative review
Main Article Content
Abstract
Oxidative stress is related to the development of multiple diseases and some studies objective to identify the effect of natural substances in lesions caused by it. One of these substances is Diosmin, a flavonoid found in citric fruits. The objective of this study was to identify through the literature the anti-oxidative effect of Diosmin. It is a descriptive and bibliographic study of integrative revision, based on articles which discussed the researched topic published between 2013 and 2017 using the electronic database PubMed and Bireme. 9 articles were analyzed. The studies evaluated show that the use of Diosmin rises the activity of enzymes which fight against oxidative stress, as catalase, superoxide dismutase and glutathione. There was reduction of the concentration of malondialdehyde. It was proved with this study that Diosmin contributes to the fight against lesions caused by the unbalance between the redox status, stimulating the rise of activity of enzymatic anti-oxidants and reducing the production of malondialdehyde, collaborating to the reduction of damage to tissues generated by stress oxidative.
Downloads
Article Details
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY) that allows others to share and adapt the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.References
Jacob KD, NorenHooten N, Trzeciak AR, Evans MK. Markers of oxidant stress that are clinically relevant in aging and age-related disease. Mech Ageing Dev. 2013;134(3-4):139-57. http://dx.doi.org/10.1016/j.mad.2013.02.008
Gasparovic AC, Jaganjac M, Mihaljevic B, Sunjic SB, Zarkovic N. Assays for the measurement of lipid peroxidation. Methods Mol Biol. 2013;965:283-96. http://dx.doi.org/10.1007/978-1-62703-239-119
McCord JM. The evolution of free radical and oxidative stress. Am J Med. 2000;108(8):652-9. https://dx.doi.org/10.1016/S0002-9343(00)00412-5
Sterba M, Popelová O, Vávrová A, Jirkovský E, Kovaríková P, Gerš V, et al. Oxidative stress, redox signaling, and metal chelation in anthracyclinecardiotoxicity and pharmacological cardioprotection. Antioxid Redox Signal. 2013;18(8):899-929. https://dx.doi.org/10.1089/ars.2012.4795
Nordberg J, Arner ESJ. Reactive oxygen species, antioxidant and the mammalian thioredoxin system. Free Rad Biol and Med. 2001;31(11):1287-312. https://dx.doi.org/10.1016/S0891-5849(01)00724-9
Barbosa KBF, Costa NMB, Alfenas RCG, Paula SO, Minim VPR, Bressan J. Estresse oxidativo: conceito, implicações e fatores modulatórios. Rev Nutr. 2010;23(4):629-43. http://dx.doi.org/10.1590/S1415-52732010000400013
McCord, JM.The evolution of free radicals and oxidative stress. Am J Med. 2000;108(8):652-9. http://dx.doi.org/10.1016/S0002-9343(00)00412-5
Betteridge, DJ. What is oxidative stress? Metabolism. 2000;49(2 Suppl 1):3-8. http://dx.doi.org/10.1016/S0026-0495(00)80077-3
Halliwell B. Oxidants and human disease: some new concepts. FASEB J. 1987;1(5):358-64. https://dx.doi.org/10.1096/fasebj.1.5.2824268
Barreiros ALBS, David JM, David JP. Estresse oxidativo: relação entre geração de espécies reativas e defesa do organismo. Quím Nova. 2006;29(1):113-23. http://dx.doi.org/10.1590/S0100-40422006000100021
Cook NC, Sammans S. Flavonoids- Chemistry, metabolism, cardioprotective effects, and dietary sources. J Nutr Biochem. 1996;7:66-76. https://dx.doi.org/10.1016/S0955-2863(95)00168-9
Tahir M, Rehman MU, Lateef A, Khan AQ, Khan R, Qamar W, et al. Diosmin abrogate schemically induced hepatocarcinogenesis via alleviation of oxidative stress, hyperproliferative and inflammatory markers in murine model. Toxicol Lett. 2013;220(3):205-18. http://dx.doi.org/10.1016/j.toxlet.2013.04.004
Tamamoto LC1, Schmidt SJ, Lee SY. Sensory profile of a model energy drink with varying levels of functional ingredients-caffeine, ginseng, and taurine. J Food Sci. 2010;75(6):S271-8. https://dx.doi.org/10.1111/j.1750-3841.2010.01655.x
Craig WJ. Health promoting properties of common herbs. Am J Clin Nutr. 1999;70(Suppl.3):491s-9. https://dx.doi.org/10.1111/10.1093/ajcn/70.3.491s
Silambarasan T, Raja B. Diosmin, a bioflavonoid reverses alterations in blood pressure, nitric oxide, lipid peroxides and antioxidant status in DOCA-salt induced hypertensive rats. Eur J Pharmacol. 2012;679(1-3):81-9. dx.https://dx.doi.org/10.1016/j.ejphar.2011.12.040
Ahmed S, Mundhe N, Borgohain M, Chowdhury L, Kwatra M, Bolshette N, et al. Diosmin modulates the NF-kB signal transduction pathways and downregulation of various oxidative stress markers in alloxan induced diabetic nephropathy. Inflammation. 2016;39(5):1783-97. http://dx.doi.org/10.1007/s10753-016-0413-4
Tanrikulu Y, Sahin M, Kismet K, Kilicoglu SS, Devrim E, Tanrikulu CS, et al. The protective effect of diosmin on hepatic ischemia reperfusion injury: an experimental study. Bosn J Basic Med Sci. 2013;13(4):218-24. http://dx.doi.org/10.17305/bjbms.2013.2305
Queenthy SS, John B. Diosmin exhibits anti-hyperlipidemic effects in isoproterenol induced myocardial infarcted rats. Eur J Pharmacol. 2013;718(1-3):213-8. http://dx.doi.org/10.1016/j.ejphar.2013.08.031
Rehman MU, Tahir M, Quaiyoom Khan A, Khan R, Lateef A, Hamiza OO, et al. Diosmin protects against trichloroethyleneinduced renal injury in Wistar rats: plausible role of p53, Bax and caspases. Br J Nutr. 2013;110(4):699-710. dx.https://dx.doi.org/10.1017/S0007114512005752
Senthamizhselvan, Manivannan J, Silambarasan T, Raja B. Diosmin pretreatment improves cardiac function and suppresses oxidative stress in rat heart after ischemia/reperfusion. Eur J Pharmacol. 2014;736:131-7. http://dx.doi.org/10.1016/j.ejphar.2014.04.026
Arab HH, Salama SA, Omar HA, Arafael-SA, Maghrabi IA. Diosmin protects against ethanol-induced gastric injury in rats: novel antiulcer actions. PloS One. 2015;10(3):e0122417. https://dx.doi.org/10.1371/journal.pone.0122417
Schlottfeldt FS, Fernandes SM, Martins DM, Cordeiro P, Fonseca CD, Watanabe M, et al. Prevenção da nefrotoxicidade da anfotericina B por meio do uso de fitomedicamentos. Rev Esc Enferm USP. 2015;49(esp)74-9. http://dx.doi.org/10.1590/S0080-623420150000700011
Hasan HF, Abdel-Rafei MK, Galal SM. Diosmin attenuates radiation-induced hepatic fibrosis by boosting PPAR-γ expression and hampering miR-17-5p-activated canonical Wnt-β-catenin signaling. Biochem Cell Biol. 2017;95(3):400-14. https://dx.doi.org/10.1139/bcb-2016-0142
Bondeva T, Wolf G. Reactive oxygen species in diabetic nephropathy: friend or foe? Nephrol Dial Transplant. 2014;29(11):1998-2003. https://dx.doi.org/10.1093/ndt/gfu037
Hasanoglu E, Altan N, Sindel S, Ongun CO, Bali M, Altintas E. The relation ship between erythrocyte superoxide dismutase activity and plasma levelsof some trace elements (AL, CU, ZN) of dialysis patients. Gen Pharmacol. 1994;25(1):107-10. https://dx.doi.org/10.1016/0306-3623(94)90018-3
Richard MJ,ArnaudJ,Jurkovitz C, Hachache T, Meftahi H, Laporte F, et al. Trace elements and lipid peroxidation abnormalities in patients with chronic renal failure. Nephron 1991;57:10-15. https://dx.doi.org/10.1159/000186208
Abdalla DSP. Antioxidantes. Conceitos básicos e perspectivas terapêuticas. ARS Cvrandi. 1993;26:141-64.
Halliwell B, Gutteridge JM, Cross CE. Free radicals, antioxidants, and human disease: where are we now? J Lab Clin Med. 1992;119(6):598-620.
Kim MJ, Lim Y. Protective effect of short-term genistein supplementation on the early stage in diabetes-induced renal damage. Mediators Inflamm. 2013;2013:510212. https://dx.doi.org/10.1155/2013/510212