Effects of risk factors in the likelihood of breast cancer subtypes in Brazilian women

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Published: Nov 8, 2021
DOI: https://doi.org/10.7322/abcshs.2020057.1505
Keywords:
breast neoplasm, parity, risk factors, age, hypertension

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Sinara Monica Vitalino de Almeida
Universidade de Pernambuco, campus Garanhuns
https://orcid.org/0000-0002-2605-4192
Felipe de Melo Souza
Solange Maria da Silva
Kleber Morais de Sousa

Abstract

Introduction: Breast cancer is a heterogenous disease with multiple causes and it lacks more investigation related to its risk factors. Objective: To evaluate the likelihood of breast cancer subtypes according to the positivity to estrogen and progesterone receptors (ER+ and PR+ respectively), with or without the expression HER2, related to the following risk factors: age, parity, diabetes mellitus, arterial hypertension, occurrence of familiar cancer case and body mass index (BMI). Methods: The sample with 79 individuals was divided into three subtypes 1 (ER+/PR-), 2 (ER+/PR+) and 3 (RE+/RP+/HER+) and then analyzed by quantitative methods using Ordinal Generalized Linear Models (OGLM) for estimating the marginal effects of risk factors for the studied subtypes, and modeling the heteroscedasticity in terms of error. Results: It were observed the following statistically significant positive effects: (1) age for the tumoral subtype 1 (ER+/PR-) and (2) parity for the subtype 2 (ER+/PR+); while the significant negative effects were: (1) age for subtype 3 (ER+/PR+/HER2+); (2) parity for both 1 (ER+/PR-) and 3 (ER+/PR+/HER2+) subtypes; and arterial hypertension for subtype 1 (ER+/PR-). There were no statistically significant effects for BMI, Diabetes mellitus and occurrence of familiar cancer variables on the studied tumoral subtypes. Conclusion: The risk factos age and parity demonstrated varied effects for the breast cancer subtypes according the expression of estrogen, progesterone and HER2 receptors.

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How to Cite
Almeida, S. M. V. de, Souza, F. de M., Silva, S. M. da, & Sousa, K. M. de. (2021). Effects of risk factors in the likelihood of breast cancer subtypes in Brazilian women. ABCS Health Sciences, 46, e021225. https://doi.org/10.7322/abcshs.2020057.1505
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Vol. 46 (2021)
Section
Original Articles

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Author Biography

Sinara Monica Vitalino de Almeida, Universidade de Pernambuco, campus Garanhuns

Professora Adjunta e pesquisadora da Universidade de Pernambuco (UPE), campus Garanhuns, doutora em Biologia Aplicada à Saúde, mestre em Bioquímica e Fisiologia pela Universidade Federal de Pernambuco (UFPE) e graduada em Biomedicina pela ASCES-UNITA. Atua como professora permanente na Pós-Graduação em Biologia Celular e Molecular Aplicada da UPE e como colaboradora na Pós-Graduação de Biologia Aplicada à Saúde-UFPE, com pesquisas desenvolvidas no Laboratório de Biologia Molecular da UPE-Garanhuns e Laboratório de Imunopatologia Keizo Asami (LIKA)-UFPE. Líder do grupo de pesquisa Oncologia Celular cujos esforços concentram-se na investigação dos processos bioquímicos e celulares em humanos e parasitas com dois objetivos distintos, mas relacionados: elucidar as bases moleculares fundamentais desses processos e estabelecer seus potenciais para intervenção farmacológica. O isolamento de enzimas e desenvolvimento de ensaios enzimáticos de inibição envolvem a colaboração com químicos medicinais para desenho e síntese de inibidores orgânicos e avaliação desses derivados nos níveis moleculares e celulares. Os trabalhos desenvolvidos incluem enzimas como topoisomerases, tirosinase e ciclooxigenase. Além disso, os novos compostos são avaliados em testes de ligação ao DNA e proteínas modelos para estudos farmacocinéticos, como por exemplo, albumina. Orienta alunos de Iniciação Científica, Mestrado e Doutorado com projetos em desenvolvimento sobre novos derivados acridínicos e indólicos e estudos imunohistoquímicos do estroma tumoral do câncer de mama. Possui colaboração com grupos da UFPE, UEPB, UNICAMP e da Universidade de Saint Andrews (Escócia).

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